Stability is one of the key parameters for the development and quality control of dispersed systems, such as emulsions, suspensions, or foams.
Assessing the stability of such systems requires reliable and sensitive methods that can detect and quantify the physical phenomena involved, such as creaming, sedimentation, flocculation, or coalescence. The TURBISCAN AGS is a high-throughput stability analyzer to shorten formulations’ time-to-market and for quality control.
The TURBISCAN AGS combines:
- TURBISCAN & SMLS technology for fast, quantitative, and reliable stability and shelf-life measurement
- Automated sample handling system working 24/7
TURBISCAN AGS is the ideal companion when dealing with large batches of samples, it operates 24/7 and without any human intervention, saving time on stability measurement and giving you the time to focus on what matters.
High-throughput stability analyzer TURBISCAN AGS The World Leader in Stability Analysis
- Accelerated destabilization detection – up to 1,000 x faster than visual observation thanks to SMLS
- Real stability: sample stability analysis without the need for dilution or mechanical stress, in concentrations up to 95%
- Fully automated robot station, working 24/7 without any user intervention
- 3 thermo-controlled storage racks (from RT to 60°C) to simulate storage conditions and accelerate even more stability evaluations
- Quantitative measurements of dispersion stability and shelf-life, migration velocity, particle size diameter, and other parameters
- One-click stability ranking with the TURBISCAN Stability Index
- Analyze up to 54 samples
Multi-sample stability analyzer TURBISCAN TRILAB Typical Applications
Whenever you are working with suspensions, emulsions, colloids, or foam, the TURBISCAN is your ideal characterization companion. The TURBISCAN series is used in various industries such as pharmaceuticals, cosmetics, food and beverage, paints and coatings, oil and gas, batteries, agrochemicals, chemistry, and much more.
emulsions
- Cosmetic creams and lotions
- Dairy products and beverages, flavor emulsions
- Pharmaceutical parenteral and topical forms
- Metalworking fluids
- Agrochemical: fertilizers, pesticides, …
- Petroleum emulsion
suspensions
- Paints, inks, and coatings
- Drug & vaccine suspension
- Make-up and sunscreen
- Chemical & polymer industry
- Ceramics and catalysts
- Battery slurries
- Electronic slurries
colloids & nanoparticles
- Drug delivery system: LNP, Liposomes, …
- Research on nanoparticles and nanoparticle suspension
- Polymer and biopolymer dispersion
… and many more!
Application examples
Fast Detection of Settling Particles Sedimentation
The TURBISCAN technology offers a significantly faster (up to 1,000 times) and more reliable detection of sedimentation compared to visual observation. Furthermore, naked-eye observation makes it difficult to calculate the migration rate and is prone to error and misinterpretation. In contrast, the TURBISCAN technology provides a fast and non-destructive way to detect and quantify sedimentation and particle size over time and can detect even small changes in highly concentrated samples without any dilution or mechanical stress. This makes it ideal for analyzing complex suspensions and formulations, and getting a quicker, reliable, and more accurate answer on sedimentation monitoring.
Fast Detection of Droplet Migration Creaming of Emulsions
When it comes to measuring droplet migration and creaming behavior in emulsion systems, the TURBISCAN technology has several advantages for formulators. On one hand, it provides a fast measurement (up to 1,000 times faster than visual observation) of native samples and a non-destructive way to detect and measure droplet migration. On the other hand, the migration rate can easily be determined and helps the formulator to compare formulas, making it ideal for analyzing complex emulsions with a wide range of droplet sizes and concentrations. Additionally, the TURBISCAN technology provides insights into the mechanisms driving droplet migration, which can be used to improve formulation and processing conditions. Overall, the use of TURBISCAN technology in emulsion analysis leads to faster, more accurate, and more reliable results compared to traditional methods.
Save Time to Measure Physical Stability Formulation: Stability Measurement and Shelf-Life Estimation
The TURBISCAN has been extensively used to measure the physical stability of formulations and colloidal systems. This technology helps the formulator to save time and precisely rank and quantify the samples’ stability in different trials or batches. It applies to native samples, even on very highly concentrated formulations. Not only saving time, the TURBISCAN also provides destabilization speed and metrics as well as robust analytics to make shelf-life predictions. The TURBISCAN technology follows ISO/TR 13097:2013’s recommendations and is ideal when it comes to quickly and accurately measuring stability. Stop the guesswork and make decisions based on facts!
What Can Be Measured Can Also Be Improved Stability Mapping: Emulsions and Suspensions
Measuring the stability of emulsions and formulations is traditionally done by visual observations. In addition to being long and tedious, the visual inspection of emulsion destabilization usually ends up with a pass / fail answer. This is suboptimal for fine-tuning the ideal concentration of surfactants or stabilizers to be added to reach the desired shelf-life. The TURBISCAN is a great help in this regard; not only does it save a huge amount of time to detect the destabilization, but it also provides a value based on the instability and ranks different formulas as a function of their shelf-life. It hence produces objective and repeatable data to make a better, greener, and safer product.
Stable Products for Safer and More Efficient Pharmaceutical Suspensions Vaccine and Parenteral Dispersions
Stability and shelf-life testing are essential for pharmaceutical products and drugs. Destabilization or instabilities in vaccines, parenteral dispersions, or pharmaceutical products can have a major impact on product efficacy, and in some cases, on patient safety. While many techniques are available, the TURBISCAN offers in-situ, non-dilution, and non-destructive measurements to detect destabilization and save time therein. It provides a clear, precise, and objective stability measurement, essential to making fast and right decisions in R&D or quality control. The TURBISCAN has been intensively used to study the stability and redispersion capability of vaccines, as well as of parenteral and injectable dispersions and providing scientists with a deep insight into the dispersion state and its evolution.
Homogenous Slurries for Higher Battery Performance Improving Battery Efficiency
There is an exponential demand for energy storage and batteries, either to cover our need for mobility and communication or to match environmental challenges. Lithium-ion batteries are the most widely used technology, and one of the key steps in developing and manufacturing them is the slurry formulation (used on the electrodes), ensuring the final battery quality. This slurry is usually highly concentrated and dark (due to a high concentration of carbon black) and using conventional light scattering techniques for evaluation is challenging or requires an important amount of dilution. The TURBISCAN has been successfully used to monitor the stability of these slurries and helps the formulator to optimize the formulation, test the production, and identify new raw materials.
High-throughput stability analyzer TURBISCAN AGS Accessories and Options
The TURBISCAN AGS comes with all you need to perform dispersibility and stability studies:
Standard Vials (20 ml)
Cylindric glass vials have a recommended volume of approximately 20 ml. They are disposable to avoid chemical or bacterial contamination and decrease labor costs for washing and drying. The vials are closed thanks to a cap and a disposable PTFE seal to prevent evaporation in case of elevated temperature. These vials are meant to reproduce your visual stability test.
Robot Handling and Gripper
Robotic movement and sample grabbing have been fine-tuned for smooth and robust sample handling from the temperature chambers to the measurement units. The cycling time for a sample is less than a minute.
Storage Racks
Between measurements, the samples are stored in temperature-controlled racks. The TURBISCAN AGS comes with 3 separate and independent sample racks and each be set from RT+5°C up to 60°C (optional: 90°C)
Calibration Standards
Each TURBISCAN comes with a set of standards to check instrument calibration. The TURBISCAN software, TURBISOFT, guides you step by step and once the procedure is finished, the software gives an “OK” signal. The test and results are saved, and the instrument checking procedure can be tracked.
Particle Size Distribution
The TURBISIZE software can measure the distribution of particle size (ISO13317) and the distribution of migration speed for any data obtained with a TURBISCAN, without any need to dilute, prepare, or modify the sample.
