ERWEKA’s flow-through cell tester DFZ II can be used for various applications thanks to its wide range of available cell types, e.g. for testing poorly soluble products or low-dose formulations with sustained release.
Innovations such as the future-proof cell design with increased leak-tightness and the optimized tubing system with quick locks allow dissolution tests to be prepared and performed quickly. The cell bodies ensure improved cell warming and can be heated individually. All USP 4 DFZ II systems can be easily controlled via a controller using the Disso.NET 3.X software.
Flow-Through Cell DFZ II New Improved Cell Design
To accompany our flow-through systems, we offer a variety of different cells with an improved design for different purposes – from standard tablet cells to granule and powder cells, as well as cells for implants, suppositories and stents.
The standardized cell head fits all cell bodies on offer and, together with the standardized flat gaskets (only 3 parts per cell: connection, head and heating jacket), facilitates handling and installation of the cells. The optimized cell bodies with reduced cell wall thickness guarantee improved cell heating.
Thanks to this concept, the cells can be mounted more easily on the DFZ II flow tester, allowing dissolution tests to be prepared and carried out more quickly.
Flow-Through Cell DFZ II Flow-Through Testing Enhanced by Innovative Design
Flow-Through Cell DFZ II Various USP 4 Cells Available
Different cells are available for different purposes – e.g. for implants, granules & powders, suppositories, stents, cells with cream adapter or with dialysis adapter.
Tablet cell (12 mm) |
Tablet cell (22.6 mm) |
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Full dissolution software solution for the flow-through cell Disso.NET USP 4
The ERWEKA Disso.NET USP 4 software is the perfect companion for all ERWEKA USP 4 systems. The software takes full control of the systems and provides support for all USP / EP dissolution cells used in them. It also supports cells for special applications (e.g. with cream adapters) and visual guides for formulation placement in the respective cells.
The software includes an easy-to-use method editor for convenient programming of dissolution methods (for maximum safety in a GMP environment). After completion of the dissolution test, Disso.NET 3.X creates comprehensive reports (as PDF files) and can export all results in various formats (e.g. as XML files).
Tailored to Your Needs USP 4 Systems
USP 4 Stand-Alone System
Easy Entry Into USP 4 Dissolution Testing
The ERWEKA stand-alone flow-through cell system is perfect for carrying out simple release tests with manual sampling. That’s why the new flow-through cell tester DFZ II in combination with the ERWEKA piston pump HKP 720 and the ERWEKA heater DH 2000i offers an easy entry into testing with USP 4 systems for a small budget.
The stand-alone system consists of:
- Piston pump HKP 720
- DFZ II flow cell + DH 2000i heater
USP 4 Open Offline System
Infinite Media Tests & Sampling
The open ERWEKA offline flow-through cell system is the perfect solution for testing poorly soluble products that require unlimited amounts of fresh media to dissolve.
With the ERWEKA sample collector FRL 754, representative samples are taken over a certain period of time for later analysis (up to 18 sampling intervals possible).
The system configuration includes:
- Piston pump HKP 720
- Flow-through cell DFZ II + heater DH 2000i
- Sample collector FRL 754
- Controller with Disso.NET USP 4 software
- One or more medium reservoirs
USP 4 Closed Offline System
Comprehensive Long-Term Testing
The closed ERWEKA offline flow-through cell system is ideal for testing low-dose formulations with sustained release (e.g. implants). It allows comprehensive long-term dissolution tests to be carried out with small media volumes.
The system configuration includes:
- Piston pump HKP 720
- Peristaltic pump IPC 8
- Flow-through cell DFZ II + heater DH 2000i
- Media transfer station LMT 2
- Sample collector FRL 754
- Controller with Disso.NET USP 4 software
USP 4 Closed Online System
Comprehensive Long-Term Tests With Integrated Analytics
The USP 4 closed online system is the automated analytical solution for the USP 4 flow-through cell. The software-controlled USP 4 system integrates USP 4 flow-through cell testing with a directly connected analytical UV/Vis online measurement, resulting in an automated USP 4 workflow.
In addition, all functions of the stand-alone system can be applied to our online system: The valveless, high-precision piston pump and the low-vibration heater keep the desired temperature of the water bath constant. And our DFZ II USP 4 cells are integrated into the software dialogs as well, making the system as user-friendly as possible.
Comprehensive Long-Term Tests With Integrated Analytics
The USP 4 closed online system is the automated analytical solution for the USP 4 flow-through cell. The software-controlled USP 4 system integrates USP 4 flow-through cell testing with a directly connected analytical UV/Vis online measurement, resulting in an automated USP 4 workflow.
In addition, all functions of the stand-alone system can be applied to our online system: The valveless, high-precision piston pump and the low-vibration heater keep the desired temperature of the water bath constant. And our DFZ II USP 4 cells are integrated into the software dialogs as well, making the system as user-friendly as possible.
Technical Data
| Weight | 8 kg |
| Dimensions (H x W x D) | 290 x 540 x 220 mm |
| Voltage | 115/220/240 V; 50-60 Hz |
| Interfaces | RS 232 (PT 100 sensors) |
| Number of cells | 7 cells in a row |
| Water bath | 6 liter volume, level indicator, emptying via 3-way-valve |
| Heating | Flow-through heater, cell warming of stations individually switchable |
| Connecting block | Connecting block with safety valve in each station |
| Temperature control | – External PT100 temperature sensor – PT100 temperature sensor in each station (optional) |
| Test cells and inserts | – Tablet cell 22.6 mm (standard) – Tablet cell 12 mm – Suppository and capsule cell – Powder & Granulate cell (USP+EP) – Stent cell – Implant cell – Gel and cream application for 22.6 mm tablet cell – One-way adapter with 22.6 mm tablet cell – Cleaning cell for system cleaning – Temperature-calibration head |
