RoboDis II+ is the only simultaneously operating, fully automatic dissolution test system currently on the market. All stages of the dissolution processes are computer-controlled and are therefore carried out completely without user intervention.
The key element of the fully automated system is the Disso.NET software developed by ERWEKA, which controls all system functions, including precise movement of the robot arm, control of the analyzers, data processing and full documentation.
In the standard configuration, the RoboDis II+ tests up to 10 batches according to USP methods 1 (basket) or 2 (paddle). The parallel sampling approach enables very short cycle times for recording detailed drug release profiles, which can be selected by the user. Integrated System Suitability Tests (SST) and video monitoring ensure a high level of reliability. Like all ERWEKA products, the RoboDis II+ is fully USP / EP / JP compliant.
Fully Automated Dissolution System RoboDis II+ Small Footprint, Great Results
Three complete semi-automatic dissolution testers including media preparation and vessel cleaning – that’s how much floor space can be saved with a RoboDis II+ 10-batch system that requires no more than 2×1 m of floor space. With the RoboDis II+, the entire dissolution process can be automated. This enables fully automated testing, including set-up, media preparation and the automatic cleaning process.
Advanced Resolution System With Numerous Functions Versatile Applications
Innovative Robodis II+ Safety Systems Not Smarter, but More Reliable
RoboDis II+ performs routine tasks more precisely than any human operator – but without a human operator, all its powerful, fully automated functions would be of no value. It is the operator who defines the test methods, checks the plausibility of the results and interprets the obtained data. To enable the operator to focus on these tasks, the RoboDis II+ has been equipped with a range of safety functions.
Fully Automated Dissolution System RoboDis II+ Product Highlights
Premium Service for a Premium Product 360° Service
Fully Automated Dissolution System RoboDis II+ Key Features
Fully Automated Dissolution System RoboDis II+ Technical Data
Weight | 760 kg, note floor load capacity |
Dimensions Housing, Transport (H x W x D) | 1800 x 2020 (total) x 1020 (total) mm |
Dimensions Housing, Installation (H x W x D) | 2800 x 2020 (total) x 1300 mm |
Power supply: Type | Tri-phase four-conductor system (L1-L3/N/PE) |
Operating voltage | 400 VAC, 50/60 Hz |
Control voltage | 24 VDC |
Power rating | approx. 5.2 kW |
Fuse | 32 A |
Water | Connections for cleaning and demineralized water max. 5 bar (0.5 Mpa) set to approx. 3-4 bar for MediPrep max. 60 °C Connection for 1/2-inch hose |
Connection for waste water with low contamination level | Connection for 3/4-inch hose |
Connection for waste water with high contamination level | Connection for 3/4-inch hose |
Height of the waste water connections | Max. 20 cm above the ground |
Connection for media tank | Norprense® hose ID 1/4-inch |
Doors | Two-leaf, makrolon, transparent, safety lock |
Robot Supplier | Festo |
Model | RP (room portal) |
Frame material | Aluminium |
Operating range | 1420 mm x 540 mm x 600 mm (xyz) |
Interfaces (control) | ModBus TCP/ EtherCAT |
Interfaces (configuration) | Standard Ethernet LAN |
Angle of rotation | 180° (electrical rotary drive) |
Robotic tools | Filling and cleaning tools, pH probe |
Number of testers | 1 |
Test stations | 7 in a row |
Test station connections | With toothed belt and gear wheel |
Agitators (shaft and stirring elements) | Stainless steel 1.4571 (316Ti) |
Stirring element | Paddle (standard), basket (optional) |
Operation | DC motor with speed sensor, sequential agitator switch (stepper motor) |
Vessel | Glass (borosilicate) |
Evaporation | Less than 1% in 24 hours |
Time measurement | Time in realtime, tolerance ± 1 sec. |
Temperature measurement | PT 100 sensor |
Temperature control | ± 0.1 °C |
Temperature in the vessel | 37 °C ± 0.5 °C; temperature range +4 °C (RT) to 40 °C ± 0.5 °C |
Stirring speed | 25 min ± 2 min up to 200 min ± 4 min |
Water bath | Acrylic glass |
Water bath volume | Approx. 30 l |
SPS | CodeSys Version 3.5 |
Other connections | PT 100 connection, heating connection and interface |
Control/operation | Controller, monitor, keyboard, mouse, WIN software |
Software | ERWEKA Disso.NET software, video software |
Heating system | Flow-through, type ERWEKA DH 1520 |
Heating capacity | 1500 W |
Flow-through speed | 6 l/min |
Interface | RS 232 |
Automatic production/degassing/heating | MediPrep (ERWEKA) |
Production | Made from up to 6 concentrates + de-ionised water or pre-mixed medium; Vmax MediPrep: 8000 ml |
Degassing | Vacuum > 190 mbar absolute |
Heating | Flow-through heating 1500 W, max 40 °C |
Dosing | Dosing via filling pump |
Scale | SST with load cell |
Pump type | Piston pump, ceramic head |
Pump Interface | RS-232 |
Vessel filling | 250 ml – 1000 ml +- 1% (volumetric filling) |
Magazines, basket | Two, each with 6 x 10 rows – USP Method 1 (only for 40-batch) |
Magazines, tablet holder | Tablet size max. ⌀ 35 mm |
HPLC device | max. 2 HPLC systems |
Automatic filter changer (opt.) | AFC (ERWEKA) |
Flow-through cuvette (opt.) | 1-10 mm |
Cleaning: Suction pump | CP 7+ diaphragm pumps |
Cleaning: Flow-through | Approx. 1000 ml/min |
Cleaning: Hoses | Norprene® |
Protection type | I/EN 61140 |
Protection class | IP 21/IEC 529 |
Ambient temperature in operation | +10 °C to +30 °C (Ambient temperature at least 5 °C lower than test temperature) |
Storage and transport temperature | +5 °C to +40 °C |
Relative humidity | 25 to 80 % non-condensing |